The Exercise Action Group
The level of physical activity is one important factor that influence if an individual with genetic predisposition to T2D will develop the disease or not. Most prospective studies assessing the impact of physical activity level on the risk of T2D indicate that regular physical activity reduces the risk of T2D by 20-30%. The benefit of exercise is apparent in both men and women independent of factors like age and obesity. It is therefore of great importance to better understand how exercise affects the physiological mechanism/s involved, and how heritable factors could influence these mechanisms. This information could potentially be highly significant for the way an individual at risk or a diabetic patient should be examined and treated in the clinic.
(1) To analyse gene expression differences induced by exercise in skeletal muscle of individuals with or without a family history (FH) of T2D
(2) To study the influence of epigenetic factors (primarily DNA methylation) on gene expression in skeletal muscle in individuals with or without a FH of T2D before and after exercise
(3) To study the influence of genetic variation, e.g. in PPARGC1A and MLYCD, on exercise response (VO2MAX and expression).
Ola Hansson (coordinator)
Marloes Dekker Nitert
Tarunveer Singh Ahluwalia