Malin Fex, associate professor
I am born and raised in Sweden, and received both my master and PhD at Lund University. The overarching goal of my research is to understand why the pancreatic beta cells fail to produce adequate amounts of insulin to regulate whole body metabolism in type 2 diabetes (T2D). I focus mainly on monoamine signaling within the islet of Langerhans and we have produced a substantial amount of work focusing on the role of serotonin and melatonin in regulation of islet function. Another focus of my research is mechanisms of autophagy, a tightly regulated process involved in cell maintenance and cell survival. Here we focus on the role of autophagy in pancreatic beta cells during metabolic stress and type 2 diabetes.
In my spare, time I like to work in my garden, exercise and spend time with my family.
Retrieved from Lund University's publications database
- Amylin alters human brain pericyte viability and NG2 expression
- An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8
- Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls
- Characterization of resident lymphocytes in human pancreatic islets
- Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
- Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
- CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
- Differential effects of three echovirus strains on cell lysis and insulin secretion in beta cell derived lines.
- Glycogen metabolism in the glucose-sensing and supply-driven β-cell
- Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
- Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men
- MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
- Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells
- Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
- The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males
- Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
- Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.
- Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
- Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.
- Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.
- Serum cytokine pattern in young children with screening detected celiac disease.
- Apelin is a novel islet peptide.
- Apelin is expressed in human and rodent islets and regulates insulin secretion
- C-peptide in dried blood spots.
- First trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age
- Pancreatic islets of melatonin receptor knock-out mice
- Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans