Yang de Marinis, Assistant professor
Epigenetics and genome engineering lab
Yang de Marinis, Principle Investigator
Pradeep Bompada, PhD student cadidate
Judit Tomènech Omella, PhD student candidate
Hyperglycamia is the culprit of diabetic complications in various tissues, owning to the complex genetic and epigenetic interactions triggered by glucose, which is the focus of our research. Specifically, we are investigating:
- The underlying glucose-associated epigeentic mechanisms of diabetic kidney dissease and cardiovascular risks.
- Function annotations of single-nucleaotide polymorphism (SNP) risk variants associated with type 2 diabetes.
- Genome engingeering in human induced pluripotent stem cells.
- Detailed investigations on function of candidate mitochondrial genes and proinflammatory genes associated with diabetes and obesity.
To facilitate our investigations, we apply cutting edge technologies that cover genome-wide chromatin immunoprecipitation sequencing, genome editing by CRISPR/Cas9, and various cell biology and molecular genetic methods.
Retrieved from Lund University's publications database
- Discriminative prediction of A-To-I RNA editing events from DNA sequence
- Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
- Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney.
- Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets
- Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.
- GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes