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Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.

Author:
  • Ole Torffvit
  • Majid Kalani
  • Jan Apelqvist
  • Björn Eliasson
  • Jan W Eriksson
  • Kerstin Brismar
  • Gun Jörneskog
Publishing year: 2012
Language: English
Publication/Series: Biochemistry Research International
Volume: 2012
Document type: Journal article
Publisher: Hindawi Publishing Corporation

Abstract english

Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG(2) despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG(2) might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.

Keywords

  • Biochemistry and Molecular Biology

Other

Published
  • Genomics, Diabetes and Endocrinology
  • ISSN: 2090-2247
E-mail: jan [dot] apelqvist [at] med [dot] lu [dot] se

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